A tale of two kinases in rods and cones
S Osawa, ER Weiss - Retinal Degenerative Diseases, 2012 - Springer
S Osawa, ER Weiss
Retinal Degenerative Diseases, 2012•SpringerMembers of the G protein-coupled receptor kinase family play essential roles in signal
turnoff for the majority of G protein-coupled receptors. GRK1, first identified almost 40 years
ago, and GRK7, the most recently identified member of the GRK family, are retina-specific
GRKs involved in the recovery and adaptation of rod and cone photoreceptors in the
vertebrate retina. This report reviews the expression patterns of these two kinases, as well
as the effect of their interaction with their substrates and binding partners. The …
turnoff for the majority of G protein-coupled receptors. GRK1, first identified almost 40 years
ago, and GRK7, the most recently identified member of the GRK family, are retina-specific
GRKs involved in the recovery and adaptation of rod and cone photoreceptors in the
vertebrate retina. This report reviews the expression patterns of these two kinases, as well
as the effect of their interaction with their substrates and binding partners. The …
Abstract
Members of the G protein-coupled receptor kinase family play essential roles in signal turnoff for the majority of G protein-coupled receptors. GRK1, first identified almost 40 years ago, and GRK7, the most recently identified member of the GRK family, are retina-specific GRKs involved in the recovery and adaptation of rod and cone photoreceptors in the vertebrate retina. This report reviews the expression patterns of these two kinases, as well as the effect of their interaction with their substrates and binding partners. The phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase (PKA) is also discussed.
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